CompletedPhase 2

Prevention of Post-Operative Nausea and Vomiting With Propofol Infusion

United States68 participantsStarted 2024-02-01

Plain-language summary

The purpose of this study is to clarify whether or not a low-dose propofol infusion can effectively prevent postoperative nausea and vomiting (PONV) in patients who have a documented history of PONV and/or motion sickness.

Who can participate

Age range18 Years

SexALL

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Inclusion criteria

✓. Undergoing general anesthesia for elective surgery
✓. Documented history of Patient's self-disclosure of PONV and/or motion sickness during pre-anesthesia discussions
✓. No documented allergy/adverse reaction to propofol
✓. English speaking
✓. At least 18 years of age

Exclusion criteria

✕. Any anti-nausea medication taken within 24 hours prior to surgery
✕. Unable to provide consent independently
✕. Allergy or adverse reaction to propofol
✕. Emergency surgery

What they're measuring

Nausea (urge to vomit) episodes

Timeframe: 24 hours

Retching (labored, spasmodic, rhythmic contractions of respiratory muscles without expulsion of gastric contents) episodes

Timeframe: 24 hours

Vomiting (forceful expulsion of gastric contents) episodes

Timeframe: 24 hours

Trial details

NCT IDNCT05759481

SponsorMilton S. Hershey Medical Center

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2025-03-12

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