WithdrawnNot Applicable

Intraoperative Identification and Stimulation of the Glossopharyngeal Nerve

Stopped: No participants have been enrolled to date.

United States0Started 2025-12

Plain-language summary

Published data suggest that the glossopharyngeal nerve innervates pharyngeal musculature important for maintenance of upper airway patency. The investigators propose a study examining the anatomic variation of the glossopharyngeal nerve and the effect of electrical stimulation on muscle recruitment and upper airway patency.

Who can participate

Age range18 Years

SexALL

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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * Consenting adults with BMI ≥ 25 and ≤ 40 kg/m2 * Planned resection of parapharyngeal space (PPS) mass without clinical evidence of cranial nerve function deficits based on physical examination * History of moderate-to-severe Obstructive Sleep Apnea (OSA) as confirmed by previous polysomnogram OR high risk for OSA based on STOP-BANG criteria (STOP-BANG score ≥ 3) Exclusion Criteria: * Unable to consent for research due to a pre-existing neurologic condition or language barriers as determined by PI * History of other primary sleep-related breathing disorder (e.g., central, or complex sleep apnea). * Previous pharyngeal surgery excluding tonsillectomy (e.g. cleft palate repair, uvulopalatopharyngoplasty) * Prior history of head and/or neck chemoradiation therapy * Existing indwelling neurostimulation device (e.g. pacemaker; spinal, vagal, or hypoglossal nerve stimulator)

What they're measuring

Change in variation in the conformation of the glossopharyngeal nerve

Timeframe: Collected during a single operative procedure, taking about 15 minutes.

Trial details

NCT IDNCT05754216

SponsorVanderbilt University Medical Center

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2027-03