CompletedPhase 4

Effect of Sildenafil Citrate Compared to Estrogen as Adjuvant Therapy for Unexplained Infertility

Egypt148 participantsStarted 2021-01-15

Plain-language summary

. This study aimed to determine and compare the effect of vaginal sildenafil citrate and estradiol valerate on endometrial thickness, blood flow and pregnancy rates in infertile women.

Who can participate

Age range20 Years – 40 Years

SexFEMALE

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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * aged between 18 to 40 years * unexplained infertility (primary or secondary) * had a regular menstrual cycle; * patent tubes; * husbands with normal semen parameters. Exclusion Criteria: * hypotension; * cardiovascular, hepatic, and renal diseases; * uncontrolled diabetes mellitus; * anovulatory infertility; * ovarian cysts; * pelvic adhesions; * hyperprolactinemia; * abnormal thyroid functions; * multiple uterine fibroids; * patients on nitrates; * suspicion of endometriosis and adenomyosis, * subjects have known to receive any treatment for fertility in the last six months

What they're measuring

pregnancy rates

Timeframe: at the end of each of 3 cycles (28 days)

Trial details

NCT IDNCT05753098

SponsorBeni-Suef University

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2023-01-31

View on ClinicalTrials.gov More Subfertility, Female trials