Dydrogesterone-Primed Ovarian Stimulation Protocol Versus Gonadotropin Releasing Hormone Antagonist Protocol in ICSI
Egypt79 participantsStarted 2023-02-20
Plain-language summary
GnRH antagonist protocol is currently a good strategy for controlled ovarian stimulation in women with PCOS undergoing IVF/ICSI cycles. Finding a protocol that can be a better alternative will help in improving the success rate of IVF/ICSI cycles
Who can participate
Age range
20 Years – 40 Years
Sex
FEMALE
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion criteria
. All patients should be candidates for ICSI.
. Age between 20-40 years.
. Body mass index 18-35 kg/m2.
. Diagnosis of PCOS according to modified Rotterdam's criteria
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1This trial compares a dydrogesterone-primed stimulation protocol to a GnRH antagonist protocol for ICSI — can you explain how these two approaches differ, and which one you currently use in my own treatment plan?
2Since this trial is measuring how many mature eggs (MII oocytes) are retrieved and the overall maturation rate, how do these numbers typically affect my chances of a successful ICSI cycle, and where do I currently stand relative to those benchmarks?
3The recruitment status for this trial is listed as unknown — can you help me find out whether it's still actively enrolling patients, or whether there's a similar study available to me right now?
4This trial is listed as Phase NA, which often applies to procedural or protocol comparison studies rather than drug safety trials — does that change the kinds of risks I should be aware of compared to a standard drug trial?
5Given that I have an ovarian cyst alongside fertility concerns, would you consider either of these stimulation protocols — dydrogesterone-primed or GnRH antagonist — more appropriate for my specific situation, whether inside or outside of a trial?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.