UnknownNot Applicable

Effects of Allium Sativum and Moringa Oleifera Extract on Dental Enamel

Pakistan90 participantsStarted 2022-12-19

Plain-language summary

Primary objective is to observe the effects of lead on dental enamel of rabbit by measuring; * Structural and morphological change by SEM, AFM * Elemental composition by SEM-EDX * Molecular composition and hydroxyapatite crystal changes by Raman Spectroscopy * Blood parameters by serum analysis Secondary objectives includes * To compare the protective effects of Allium sativum and Moringa oleifera on dental enamel defects due to lead * To determine the beneficial effects of AS and MO extract in remineralization of dental enamel.

Who can participate

Age range

3 Months – 5 Years

Sex

MALE

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * Healthy rabbits * Rabbits Age 9-10 weeks * Weight 1000-1200 g will be selected Exclusion Criteria: * Diseased rabbit * Age: More than 10 weeks and less than 9 weeks * Weight more than 1200 g and less than 1000 g

Questions worth asking your doctor

Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.

1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?

Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.

Questions for the trial coordinator

The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.

1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?

A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.

What they're measuring

Histological Outcomes

Timeframe: at the end of the study

Trial details

NCT IDNCT05744752

SponsorArslan Saleem

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2023-05

View on ClinicalTrials.gov More Lead Poisoning trials