CompletedNot Applicable

Effects of Dexmedetomidine/Lidocaine/Intrathecal Morphine on Cancer Metastasis Biomarker After Colorectal Surgery

South Korea114 participantsStarted 2023-04-12

Plain-language summary

This is a prospective randomized controlled trial. Investigators aimed to compare the effect of three different anesthetic adjuvants (continuous infusion of lidocaine or dexmedetomidine, intrathecal morphine injection) on the biomarker for cancer recurrence and metastasis. Patients undergoing elective colorectal cancer surgery will be randomly allocated to three parallel arms and the biomarkers for cancer recurrence and metastasis, inflammation, and immune response will be compared. And we will compare the clinical outcomes in the three method.

Who can participate

Age range19 Years

SexALL

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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * Patients who were scheduled for elective colorectal cancer surgery American Society of Anesthesiologists physical status of I-III Exclusion Criteria: * Atrioventricular conduction disorder * Having Bradycardia (\<50 bpm) * Severe pulmonary dysfunction in pulmonary function test * High risk for cardiovascular complications(expected postoperative event \>5%) * Allergy or hypersensitivity reaction to each adjuvant. * History or risk factors for Malignant hyperthermia * Body mass index \>40 kg/m2

What they're measuring

MMP-9

Timeframe: 1 hour after surgery

Trial details

NCT IDNCT05742438

SponsorSamsung Medical Center

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2023-07-05

View on ClinicalTrials.gov More Colorectal Cancer trials