Quality and Biologic Characteristics of Red Blood Concentrates Obtained From Individuals With Elevated Ferritin.

Inclusion Criteria: * Age:18-75 years * Body weight \> 50 Kg * Haemoglobin ≥ 135 g/l (males), ≥ 125 g/l (females) * In subjects of the HH and non-HH group: ferritin values \>500 ng/ml, which must have been measured in the last three months before the inclusion in the study (either at the Blood Donation service or elsewhere), not followed by a blood donation or a phlebotomy * In subjects of the HH group: genetic test demonstrating the presence of p.C282Y homozygous or p.C282Y/p.H63D compound heterozygous HFE-gene mutation * In subjects of the control group: ferritin values \< 300 ng/ml (males) or \< 200 ng/ml (females) * Written informed consent to the participation in the study Exclusion Criteria: * Inadequate vein access for whole blood collection * Body weight \< 50 kg * Chronic viral infection (hepatitis B or C, HIV) * Previous acute coronary heart disease * Previous or current history of epilepsy * Other severe conditions that could significantly increase the phlebotomy risk, based on individual medical evaluation * No informed consent * Pregnancy (according to the information on the standard blood donor questionnaire)