The Efficacy of Pasteurised Akkermansia Muciniphila in Healthy Medical Workers

Inclusion Criteria: * Working in a high stress hospital department, like: emergency, trauma, intensive care, surgery, internal diseases; * Written informed consent to participate in this study before any study-mandated procedure; * Body mass index (BMI) ≥18.5 kg/m2 and ≤ 35 kg/m2; * A willingness and motivation to follow the study protocol. Exclusion Criteria: * Diagnosis of autoimmune, neurological, immunocompromised, thyroid, inflammatory bowel diseases, irritable bowel syndrome, diabetes, cancer, and/or IgE-dependent allergy; * Psychiatric comorbidities, including mental retardation, organic brain dysfunction, or addiction (except nicotine and caffeine), intake of antipsychotic and antidepressive drugs; * Proton pump inhibitors usage; * The use of antibiotics and/or probiotics 4 weeks prior to the study; * Glucocorticosteroids and/or metformin treatment; * Dietary supplementation (except for vitamin D) within the three months before screening; * Specific restrictive (e.g. elimination, vegan, FODMAP, reduction) diet within the three months before screening; * Significant changes in physical activity 4 weeks before the trial entry; * Pregnancy or lactation; * Significant GI surgery within the last 6 months prior to or planned during the study; * Any other medication for management of IBS complaints like peppermint oil, bile acid binders; * Lactose intolerance; * Participation in another study during the last 30 days prior to and during the study; * Any other reason for ex…