CompletedPhase 3

Epinephrine Nebulization Prior to Nasotracheal Intubation

Egypt126 participantsStarted 2021-09-01

Plain-language summary

This randomised, prospective study performed in Ain shams university hospitals over 126 Patients ASA I and ASA II, trauma patients who suffered isolated mandibular fractures and necessitated nasal intubation during general anesthesia. The patients were randomly assigned to one of two equal groups: nasal Lidocaine drops followed by Oxymetazoline nasal drops group (OL) or Epinephrine mixed with Lidocaine as nebulization session (EL) group.

Who can participate

Age range18 Years

SexALL

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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * Cases with American Society of Anesthesiologists (ASA) classes I and II. * Patients scheduled for elective oral isolated mandibular fracture fixation requiring nasotracheal intubation. Exclusion Criteria: * Nasal abnormality history (such as polyp , surgery or nasal trauma). * Frequent epistaxis history. * Patients suffering valvular heart disease, hypertension, ischemic heart disease or arrhythmias. * Patients using drugs (anticoagulation therapy, non-steroidal anti-inflammatory drugs, and oral decongestants). * Patients receiving medications known to alter the parameters under investigation including β-blockers, calcium channel blockers, or vasodilators. * Patients known to have hypersensitivity to medications used in this study.

What they're measuring

estimate the degree of epistaxis

Timeframe: the whole intraoperative time

Trial details

NCT IDNCT05738564

SponsorAin Shams University

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2022-04-30

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