Effect of Electric Impedance Tomography-Guided PEEP Titration (NCT05736185) | Clinical Trial Compass
CompletedNot Applicable
Effect of Electric Impedance Tomography-Guided PEEP Titration
China69 participantsStarted 2023-02-25
Plain-language summary
Acute respiratory syndrome distress (ARDS) is a clinical common syndrome with high mortality. Mechanical ventilation (MV) is the cornerstone of management of ARDS but can lead to ventilator-induced lung injury. Positive end-expiratory pressure (PEEP), as one of main component of MV, has been widely used in the clinical practice. However, how to best set PEEP is still a difficult problem for moderate to severe ARDS patients. EIT, an imaging tool evaluating the regional ventilation distribution at the bedside, can achieve the individual PEEP selection for all mechanically ventilated patients. This article compared the effect of PEEP titrated guided by EIT with fraction of inspired oxygen (FiO2)-PEEP table on the ventilation-perfusion mismatch.
Who can participate
Age range
18 Years
Sex
ALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion criteria
. Intubated patients with moderate and severe ARDS (Berlin definition, PaO2/FiO2 ≤200 mmHg at PEEP 5 cmH2O)
. undergoing deep sedation on controlled mechanical ventilation within72 hours after ARDS onset
Exclusion criteria
. age \<18 years old
. patient undergoing legal protection
. contra-indications to EIT (e. g. severe chest trauma or wounds)
. pneumothorax
. patient undergoing ECMO
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1This trial compared three different PEEP (pressure) settings for ventilators in ARDS patients — can you explain what PEEP means for my situation and whether the way my ventilator pressure is currently set follows any of these approaches?
2The study used a technology called Electrical Impedance Tomography to guide ventilator settings — is this technology available at this hospital, and could it change how my breathing support is managed?
3Since this trial is now completed, have the results been published yet, and if so, did the EIT-guided approach show any meaningful improvement in how well oxygen gets matched to blood flow in the lungs compared to standard pressure settings?
4This trial was listed as 'Phase NA,' meaning it focused more on measuring how the body responds than on testing a new drug — does that mean the findings are more about refining existing ventilator techniques rather than introducing something entirely new to my care?
5Given that this study looked specifically at ventilation-perfusion mismatch in ARDS, how does my current lung function compare to the kind of patients enrolled, and is optimizing my ventilator PEEP setting something my care team is actively considering?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.
What they're measuring
1
Difference in ventilation-perfusion mismatch between EIT-PEEP, low-PEEP, and high PEEP