Influence of Oxycodone on Individuals Taking an SSRI

Inclusion Criteria: * Signed the informed consent form (ICF) and able to comply with the study requirements and restrictions listed therein; * Male and female subjects, age 18 to 75 years, inclusive; * Women of childbearing potential (defined as all women who are not surgically sterile or postmenopausal for at least 1 year prior to informed consent) must have a negative serum pregnancy test prior to enrolment and must agree to use a medically acceptable means of contraception from screening through at least 1 month after the last dose of study drug; * Body Mass Index (BMI) 18 to 35 kg/m2, inclusive; * Stable as defined by the Investigator, based on a medical evaluation that includes the subject's medical and surgical history, physical examination, vital signs; * Using sertraline (minimal dose 50 mg), paroxetine minimal dose 20 mg), citalopram (minimal dose 20 mg) or escitalopram (minimal dose 10 mg). Exclusion Criteria: * Currently meet the criteria for diagnosis of moderate or severe substance use disorder according to the DSM-5 criteria on any substances other than caffeine, or nicotine; * Any active medical condition, organ disease or concurrent medication or treatment that may either compromise subject safety or interfere with study endpoints; * Consume, on average, \>27 units/week of alcohol in men and \>20 units/week of alcohol in women (1 unit = 1 glass (250 mL) beer, 125 mL glass of wine or 25 mL of 40% spirit); * Currently receiving medication-assisted treatment f…