WithdrawnNot Applicable

Starling/CRRT Observational Study

Stopped: Study Sponsor decided not to move forward with this project.

United States0Started 2023-07-15

Plain-language summary

Hemodynamic optimization of critically ill patients is a goal for clinicians in order to afford the patient the best possible outcomes. Being able to precisely and rapidly determine patient fluid responsiveness provides the bedside physician and nursing staff the information needed to make critical decisions in regard to the patient's fluid status and management of additional fluids and medications. As fluid management and cardiac output determination are linked to better decision-making and improved outcomes in ICU, the use of a dynamic assessment of fluid responsiveness becomes a key tool for patient management. This study is designed to collect treatment and outcome data on patients that have undergone hemodynamic monitoring during CRRT therapy.

Who can participate

Age range

18 Years – 95 Years

Sex

ALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion criteria

. ≥18 to 95 years of age.
. Patient has undergone hemodynamic monitoring with the Starling monitor during a CRRT treatment.
. Hemodynamic monitoring was completed no earlier than 2018

Exclusion criteria

. Patients did not have an arterial line in place during CRRT treatment
. Patients on extracorporeal membrane oxygenation (ECMO) or left ventricular assist device (LVAD)
. Patients with end-stage kidney disease on chronic dialysis

Questions worth asking your doctor

Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.

1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?

Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.

Questions for the trial coordinator

The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.

1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?

A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.

What they're measuring

Change in stroke volume (SV) after CRRT initiation

Timeframe: Day 1 (during CRRT)

Change in cardiac output (CO) after fluid removal

Timeframe: Day 1 (during CRRT)

Change in cardiac index (CI) after fluid removal

Timeframe: Day 1 (during CRRT)

Change in stroke volume (SV) after fluid removal

Timeframe: Day 1 (during CRRT)

Change in stroke volume index (SVI) after fluid removal

Timeframe: Day 1 (during CRRT)

Change in Thoracic Fluid Content (TFC) after fluid removal

Timeframe: Day 1 (during CRRT)

Change in heart rate (HR) after fluid removal

Timeframe: Day 1 (during CRRT)

Trial details

NCT IDNCT05729048

SponsorBaxter Healthcare Corporation

Sponsor typeINDUSTRY

Study typeOBSERVATIONAL

Primary completion2025-03-14

View on ClinicalTrials.gov More Hemodynamic Monitoring trials

Plain-language summary

Who can participate

Age range

18 Years – 95 Years

Sex

ALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion criteria

. ≥18 to 95 years of age.
. Patient has undergone hemodynamic monitoring with the Starling monitor during a CRRT treatment.
. Hemodynamic monitoring was completed no earlier than 2018

Exclusion criteria

. Patients did not have an arterial line in place during CRRT treatment
. Patients on extracorporeal membrane oxygenation (ECMO) or left ventricular assist device (LVAD)
. Patients with end-stage kidney disease on chronic dialysis

What they're measuring

Change in stroke volume (SV) after CRRT initiation

Timeframe: Day 1 (during CRRT)

Change in cardiac output (CO) after fluid removal

Timeframe: Day 1 (during CRRT)

Change in cardiac index (CI) after fluid removal

Timeframe: Day 1 (during CRRT)

Change in stroke volume (SV) after fluid removal

Timeframe: Day 1 (during CRRT)

Change in stroke volume index (SVI) after fluid removal

Timeframe: Day 1 (during CRRT)

Change in Thoracic Fluid Content (TFC) after fluid removal

Timeframe: Day 1 (during CRRT)

Change in heart rate (HR) after fluid removal

Timeframe: Day 1 (during CRRT)