CompletedNot Applicable

Colloid Infusion for Optimal Outcomes In Non-cardiac Surgery (COIN Trial)

China2,022 participantsStarted 2023-07-12

Plain-language summary

Hypotension is associated with postoperative complications. Preoperative fluid infusion can effectively prevent post-induction hypotension of general anesthesia. Previous studies only focused on the hemodynamics after preoperative fluid infusion. Pre-operative fluid infusion can reduce the incidence of post-operative complications by preventing post-induction hypotension. The patients who is 18 years or older and undergo elective non-cardiac surgery with general anesthsia will be enrolled. The intervention is intravenous infusion of colloids or crytalloids before induction of general anesthesia. The primary outcome is the incidence of post-operative complications within 30 days.

Who can participate

Age range

18 Years

Sex

ALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * 18 years or older * ASA I-III * Undergoing elective non-cardiac surgery under general aneathesia Exclusion Criteria: * Allergic to colloids * Severe heart diseases ( Ejection Fraction lower than 35%) * Presence of renal failure pre-operatively (defined as eGFR \< 30 mL/min/1.73 m2 and/or patient receiving renal replacement therapy) * Morbid obesity (BMI \> 37.5kg/m2 or \> 32.5kg/m2 with metabolic diseases) * Presence of a coagulopathy at screening (defined as platelet count \< 100 × 109/L and/or a prothrombin time \< 70% and/or an activated partial thromboplastin time (aPTT) \>35 s and/or fibrinogen \<1 g/ L) * Presence of liver injury (defined as Child-Pugh C) * Pre-operative electrolyte disturbances with Na \>160 mmol/L or \<120 mmol/L * Patients with preoperative intracranial hypertension requiring dehydration treatment

Questions worth asking your doctor

Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.

1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?

Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.

Questions for the trial coordinator

The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.

1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?

A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.

What they're measuring

The incidence of post-operative complications

Timeframe: within 30 days after operation

Trial details

NCT IDNCT05728645

SponsorXijing Hospital

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2025-03-28

View on ClinicalTrials.gov More Postoperative Complications trials