CompletedPhase 3

Intubation Conditions After RSI Using Rocuronium with Ephedrine Pretreatment

Egypt75 participantsStarted 2023-04-01

Plain-language summary

This trial will study if ephedrine pretreatment before low doses of rocuronium (0.6 or 0.8 mg/kg) would provide similar intubating conditions as with the high dose of 1.2 mg/kg in patients undergoing RSII.

Who can participate

Age range18 Years – 60 Years

SexALL

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Inclusion Criteria: * ASA physical status I or II Exclusion Criteria: * Neuromuscular disease: myopathies * On drugs that interact with the neuromuscular junction or ephedrine * Cardiovascular disease: hypertension or ischemic heart disease * Increased risk of pulmonary aspiration: * GERD * Pregnancy * Anticipated airway difficulties: * Mallampati grade III or IV * Obesity (BMI ≥30 kg/m2), * Hypersensitivity to any of the study drugs

What they're measuring

Intubation conditions

Timeframe: after 60 seconds of rocuronium administration

Trial details

NCT IDNCT05725031

SponsorAin Shams University

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2024-02-01

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