An Evaluation of Salivary Oxidant and Antioxidant Levels in Peri-implant Health and Disease (NCT05724706) | Clinical Trial Compass
CompletedNot Applicable
An Evaluation of Salivary Oxidant and Antioxidant Levels in Peri-implant Health and Disease
88 participantsStarted 2016-09-01
Plain-language summary
Objectives: Inflammatory lesions develop in the tissues surrounding implants are referred to as peri-implant diseases. Oxidants, play a role in inflammatory lesions. The study aimed to determine oxidant and antioxidant levels in the saliva of patients with various levels of peri-implant diseases and the relationship between oxidative stress and peri-implant diseases.
Material and methods: Sixty-seven patients with at least one dental implant applied in our clinic were included in the study. The patients were divided into 3 groups; with peri-implantitis (PI), with marginal bone loss (MBL) and with healthy peri-implant (HI) tissues. Twenty-one individuals who didn't have any dental implants were included the study as a healthy control group (HC). For oxidant concentration, total oxidant status (TOS), advanced oxidation protein products (AOPP), and for antioxidant concentration, total antioxidant status (TAS), were investigated.
Who can participate
Age range
18 Years – 67 Years
Sex
ALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria:
* Adults aged 18 and older;
* Being systemically healthy; ,
* Being non-smokers;
* For dental implant groups, at least 1 osseointegrated implant;
* Dental implant applied by at least a specialist-level physician;
* Dental implants having the same surface and the same design;
* Correct prosthetic restoration of occlusal loading;
* Dental implant having been in function for at least 6 months.
Exclusion Criteria:
* Any history of medical conditions;
* Presence of active periodontal disease;
* Use of antibiotic or anti-inflammatory medications in the past 3 months;
* Pregnancy;
* Use of AO supplements;
* Smoking;
* Poor oral hygiene;
* Inflammation in the oral area;
* Presence of active caries;
* Presence of oral mucosal lesions such as oral lichen planus or recurrent aphthous stomatitis.
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.
What they're measuring
1
Identifying patients to be included in the study and collecting saliva samples