NIVATS Versus IGAVATS: a Pilot Trial Addressing Biopsy Quality in Undetermined Interstitial Lung Diseases

Inclusion Criteria: * Patient with purported interstitial lung disease * Patient requiring a surgical lung biopsy to reinforce diagnosis according to current recommendations and validated by a multidisciplinary assessment * Minimum age: 18 years Exclusion Criteria: * Contra-indication for surgery * Uncontrolled oesophageal gastric reflux despite optimal treatment * Thoracic deformation (For example, pectus excavatum/carinatum or major scoliosis) * Risk of pleural adhesion (For example, patient who has already undergone thoracic surgery) * History of abnormal bleeding * Predictable risk of difficult intubation * Body mass index (BMI) \> 30 * Severe cardiovascular comorbidity (For example, instable ischemic cardiomyopathy) * Unable to comply with all trial procedures/visits (For example, language barriers, upcoming move of household to another region, unwillingness to schedule the required followup visits.) * Protected populations according to the French Public Health Code Articles L1121-5,6,8 (For example, pregnant, parturient or lactating women, prisoners, adults under guardianship or otherwise unable to consent.) * Potential interference from another study (The patient is participating in another interventional study, or has done so in the past month, or is affected by an exclusion period stipulated by a previous study.) * Non-beneficiary of the French single-payer national medical insurance system * Lack of signed informed consent