Ocular surface temperature of a normal person is around 34.6 degree centigrade. After instilling the eye drop, depending on the temperature of the eye drop and the ocular surface, the ocular surface temperature will temporally increase or decrease sightly. Warm feeling will make blood vessels dilated and more blood will pass through to bring more blood flow out of our body to the heated area of the body and makes cells more permeable. Therefore, heating the ocular surface with heated eye mask after instilling artificial tears has the possibility to improve drug permeability on the ocular surface.
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Non-invasive tear break-up time (NIBUT)
Timeframe: Day-0 (baseline), day-7, and day-14
Ocular Surface Disease Index (OSDI)
Timeframe: Day-0 (baseline), day-7, and day-14