CompletedNot Applicable

Precision Exercise Therapeutics (PET-pilot)

Denmark24 participantsStarted 2023-03-01

Plain-language summary

The aim of this randomized cross-over study is to collect information for the design of a precision exercise therapy cohort that will predict what modality of physical activity a physically inactive individual with overweight should perform to increase insulin sensitivity given their unique biology, environment, and context.

Who can participate

Age range40 Years – 90 Years

SexALL

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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * BMI\>25 * Age\> 40 years * Inactivity, defined as \< 1,5 hours of structured physical activity pr. week at moderate intensity and cycling \< 30 minutes/5 km pr. day at moderate intensity (moderate intensity = out of breath but able to speak) Exclusion Criteria: * • HbA1c\>53 mmol/mol * Uncontrolled hypertension * Uncontrolled hyperlipidemia, * Known hyperthyroid disease * Endocrine disorders causing obesity * Known autoimmune disease * Unstable cardiovascular disease * Glucose lowering medications except for low dose metformin (=\<1000 mg/day) * Current treatment with anti-inflammatory medication, unless pain killers without prescription * No participation in other research intervention studies * Pregnancy/considering pregnancy within the study period * Conditions countering exercise

What they're measuring

24 hour change in insulin sensitivity (Matsuda index) derived from a 2-hour Oral Glucose Tolerance Test

Timeframe: 6 weeks

Trial details

NCT IDNCT05718089

SponsorRigshospitalet, Denmark

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2023-12-31

View on ClinicalTrials.gov More Overweight trials