UnknownNot Applicable

Effect of Ulinastatin on the Action of NDMRs (Rocuronium / Cisatracurium)

China80 participantsStarted 2023-02-15

Plain-language summary

The aim of this research was to determine the influence of ulinastatin on nondepolarising muscle relaxants Rocuronium and Cisatracurium.

Age range25 Years – 60 Years

SexALL

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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

✓. Patients undergo elective pancreaticoduodenectomy surgery
✓. Age ranging from 25 to 60 years，body mass index (BMI)18-24kg/m2, American Society of Anesthesiologists (ASA) grades 1 or 2.
✓. Receive general anesthesia and muscle relaxants intraoperatively.

✕. patients ASA class 3 and above
✕. Severe cardiac or respiratory diseases, liver or kidney disease
✕. Pregnant women.
✕. Patients with neurological dysfunction including myasthenia gravis, epilepsy or psychiatric disorders
✕. Patients on any premedications including antisialagogues .
✕. Patients on drugs known to interfere with neuromuscular transmission including but not exclusive to anticonvulsants, calcium channel blockers, β-blockers, corticosteroids, diuretics and antibiotics of the aminoglycoside group
✕. Patients known allergy to propofol and sufentanil or remifentanil,
✕. emergency operations.

Onset time

Timeframe: 1 day

RT1

Timeframe: 1 day

RT2

Timeframe: 1 day

RT3

Timeframe: 1 day

RT4

Timeframe: 1 day

Duration of moderate neuromuscular block (RT1-RT4)

Timeframe: 1 day

Duration 25%

Timeframe: 1 day

Duration 50%

Timeframe: 1 day

Duration TOF 0.7

Timeframe: 1 day

NCT IDNCT05716256

SponsorHuazhong University of Science and Technology

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2023-06-15

Ai Ling