Effect of Subanesthetic Dose of Esketamine on Sleep Quality and Recovery of Gastrointestinal Func… (NCT05715671) | Clinical Trial Compass
CompletedNot Applicable
Effect of Subanesthetic Dose of Esketamine on Sleep Quality and Recovery of Gastrointestinal Function in Patients Undergoing General Anesthesia Laparoscopic Uterine Surgery in the Early Postoperative Period
China138 participantsStarted 2023-03-25
Plain-language summary
Patients undergoing gynecological surgery are at high risk of developing postoperative sleep disorders. Intraoperative opioid use is detrimental to the patient's postoperative recovery of gastrointestinal function. Esketamine has sedative, hypnotic, analgesic, inflammatory response suppression, and antidepressant effects. Its hypnotic mechanism may be related to its rapid blockade of NMDA receptors and hyperpolarization-activated cyclic nucleotide-gated cation channels. Also can reduce the application of perioperative opioids, which in turn promotes the recovery of gastrointestinal function in patients after surgery.
Who can participate
Age range40 Years – 65 Years
SexFEMALE
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Inclusion criteria
✓. Age between 40 and 65 years;
✓. ASA class I-III;
✓. Proposed laparoscopic total hysterectomy/myomectomy;