Genetic Evaluation and Modification of Lifestyles to Improve Female Life Expectancy

Inclusion Criteria: * Non-hysterectomized women: Amenorrhea \> 12 consecutive months * Hysterectomized women: Bilateral oophorectomy (3 months after surgery) * Normal mammogram in the past year * Normal pap smear deemed to be negative within 5 years * Able to understand the protocol and sign an informed consent * Able to participate in a structured diet program for 12 weeks * Able to participate in a structured walking program for 12 weeks * Able to participate in a structured mindfulness-stress reduction program * Able to operate an I-PAD, and able to connect to the internet Exclusion Criteria: * Known or suspected pregnancy * Undiagnosed abnormal vaginal bleeding * Known or suspected breast cancer or estrogen-dependent neoplasia * Known or at risk for a MI, PE or significant cardiovascular event * Poorly controlled blood pressure : sitting systolic \> 160 or diastolic \>95 mmHg * Poorly controlled diabetes * Uncontrolled thyroid disease * Impaired liver function * Unstable psychiatric disorder including depression or anxiety, PTSD * History of drug or alcohol abuse * Treatment with anticoagulants ( heparin, warfarin, lovenox, eliquis) * Severe systemic disease which might interfere with interpretation of results * Unwilling or unable to follow a diet, exercise or stress reduction protocol