Selective Lipopolysaccharide Hemosorption in Maternal Sepsis

Inclusion Criteria: * Age ≥18 years * An established diagnosis of sepsis according to the criteria for SEPSIS-3, most likely Gram-negative etiology, at the time of inclusion. * No more than 12 hours from the time of setting DS - Sepsis and/or Septic Shock. In case of septic shock: • Hypotension requiring vasopressor support for at least 2 hours continuously and no more than 12 hours. In the absence of Septic shock, but in the presence of suspicion of sepsis (before the detection of flora) and organ dysfunction, inclusion in the clinical trial is based on 2 of the 4 SIRS criteria, • SOFA ≥ 4 points. Exclusion Criteria: * Inability to obtain informed consent from the patient, family member or legal representative, * The presence of a focus of non-sanitized surgical infection, * The use of other methods of extracorporeal removal of LPS and inflammatory mediators in the treatment of septic shock (hemofilters with highly permeable and surface-modified membranes) * In Septic Shock, failure to achieve or maintain a minimum mean arterial pressure (MAP) ≥ 65 mmHg. Art., despite vasopressor therapy and infusion therapy for 24 hours, * End-stage renal disease and need for chronic dialysis. * Acute pulmonary embolism * Transfusion reaction, * Severe congestive heart failure, * Uncontrolled bleeding (acute blood loss in the last 24 hours), * Severe granulocytopenia (white blood cell count less than 500 cells/mm3), * Any other condition that, in the opinion of the investigator, woul…