REALITY MONITORING AND DOPAMINE (NCT05711082) | Clinical Trial Compass
RecruitingNot Applicable
REALITY MONITORING AND DOPAMINE
France39 participantsStarted 2024-01-15
Plain-language summary
Reality-monitoring characterizes the ability to determine whether information was perceived in the environment or only imagined . Impaired reality-monitoring abilities have been associated with hallucinations in patients with schizophrenia and patients with Parkinson's disease.
The investigators hypothesize a link between dopaminergic (DA) transmission and reality-monitoring.
Who can participate
Age range
18 Years – 45 Years
Sex
ALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria:
* Healthy volunteers who have given their written informed consent
* Men and women from 18 to 45 years old
* Normal or corrected vision
* Being fluent in French or French for native language
* Being affiliated with health insurance
Exclusion Criteria:
* Healthy volunteers who have given their written informed consent
* Men and women from 18 to 45 years old
* Normal or corrected vision
* Being fluent in French or French for native language
* Being affiliated with health insurance
* Inadmissibility of the subject's consent or refusal
* Working-memory deficit (as controlled with MMSE score\< 23)
* Any past or current psychiatric or somatic condition(as controlled with the Mini International Neuropsychiatric Interview, MINI)
* Any past or current neurological condition
* History of cranio-cerebral trauma, arterial hypotension or hypertension, cardiological or serious medical condition
* Abnormal potassium dosage (below 3.1 mmol/L or above 4.9 mmol/L)
* Anormal ECG
* History of schizophrenia or bipolar disorder in first-degree relatives
* Alcohol-drinking and caffeine intake at least during 24 hours before each session
* Drug therapy excepting contraceptives
* Cardiologic or severe medical conditio
* Pregnancy(checked with a pregnancy autotest), lactation, or insufficient contraceptive measure (precautionary measure)
* Consumption of recreational drugs during the last 6 months
* Known sensitivity to any of the study medication and their excipients
* Lactose …
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.