Active — Not RecruitingNot Applicable

Longitudinal Assessment of Brain Structure and Function in Juvenile-onset Huntington's Disease

United States37 participantsStarted 2020-01-01

Plain-language summary

The goal of this observational study is to learn about brain development in Juvenile-onset Huntington's Disease (JoHD). The main questions it aims to answer are: * Is brain development different in JoHD than Adult-onset Huntington's Disease (AoHD)? * Can reliable biomarkers for JoHD be found in brain structure and function? Participants will be asked to complete cognitive tests, behavioral assessments, physical and neurologic evaluation, and MRI. Data collected will be compared to populations who are at-risk for HD and who have been diagnosed with HD as adults.

Who can participate

Age range4 Years – 30 Years

SexALL

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Inclusion Criteria: * Clinical diagnosis of JoHD * Aged 4-30 Exclusion Criteria: * Metal in body * History of head trauma, brain tumor, seizures or epilepsy unrelated to JoHD * History of major surgery or serious chronic medical conditions other than JoHD

What they're measuring

Volume of brain structures as measured by Magnetic Resonance Imaging (MRI)

Timeframe: 60-90 minutes out of 7-8 hour testing day

Trial details

NCT IDNCT05707663

SponsorUniversity of Iowa

Sponsor typeOTHER

Study typeOBSERVATIONAL

Primary completion2026-08-31

View on ClinicalTrials.gov More Juvenile Huntington Disease trials