. Normal clinical results from a medical exam reviewed by a board-certified physician (e.g., General Health Questionnaire - see attached document)
. Body mass index (BMI) \<40 unless athletic/muscular build; calculation = body weight (kg)/height (m2)
. Females Only: Post-menopausal
Exclusion criteria
. Not meeting the age criteria
. Body mass index (BMI) \>40 unless athletic/muscular build; calculation = body weight (kg)/height (m2)
. Use of tobacco or nicotine products within the last 6 months (tobacco cigarettes, chewing tobacco, nicotine patches or gum)
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.
What they're measuring
1
6 minute walk test
Timeframe: Before sham or heat therapy
2
6 minute walk test
Timeframe: After 8 weeks of heat therapy or sham
3
Macrovascular function
Timeframe: Before sham or heat therapy
4
Macrovascular function
Timeframe: After 8 weeks of heat therapy or sham
5
Microvascular function
Timeframe: Before sham or heat therapy
6
Microvascular function
Timeframe: After 8 weeks of heat therapy or sham
7
Blood flow response to exercise
Timeframe: Before sham or heat therapy
8
Blood flow response to exercise
Trial details
NCT IDNCT05706181
SponsorUniversity of North Texas Health Science Center
. Not abstaining from the following 24 hours prior to the experimental session: exercise, alcoholic substances, prescription or non-prescription medications (unless cleared by the medical screener), dietary supplements, herbal medications, caffeinated substances (including chocolate, coffee, tea (iced or hot), caffeinated energy drinks, and sodas)
. S who weigh less than 80 lbs
. Use of prescription drugs, non-prescription drugs or herbal medicines known to alter vascular function unless cleared prior to the study