Clinical Investigation Evaluating Safety and Efficacy of Selective Intra-arterial 166Holmium Radi… (NCT05705791) | Clinical Trial Compass
TerminatedNot Applicable
Clinical Investigation Evaluating Safety and Efficacy of Selective Intra-arterial 166Holmium Radiation Therapy in Combination With Atezolizumab and Bevacizumab for Non Resectable Hepatocellular Carcinoma
Stopped: Toxicities
France10 participantsStarted 2023-02-07
Plain-language summary
The goal of this clinical trial is to evaluate the added value of 166Holmium SIRT to Atezolizumab-Bevacizumab in patients with non resectable HCC. The primary endpoint is the Best Objective Response Rate at 6 months after 166Holmium SIRT according to mRECIST.
Participants will be treated by :
* Approved first line systemic therapy: Atezolizumab (1200mg Q3W, IV) with Bevacizumab (15mg/kg Q3W, IV)
* In combination with 166Holmium selective internal intra-arterial radiation therapy (Quirem Spheres®, the investigational medical device) after a work-up phase considered as "favorable".
Participants will be followed up to 12 months after the first cycle of Atezolizumab and Bevacizumab therapy.
Who can participate
Age range
18 Years
Sex
ALL
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1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
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