UnknownPhase 4

Acetated Ringer´s Solution in Experimental Hypovolemia

Norway12 participantsStarted 2024-03-02

Plain-language summary

Intravenous fluids are often given to increase stroke volume and thereby improve global oxygen delivery. The effect is however often transient, but the effect of a fluid bolus on stroke volume and other hemodynamic variables over time are poorly described. The volume effect of a fluid bolus (effect on blood volume) can be calculated by measuring Haemoglobin. The purpose of this study is to elucidate the hemodynamic effects of a fluid bolus during normovolemia and hypovolemia in healthy volunteers. Study details include: • Study Duration: 2 visits of approximately 2 h duration each + follow-up visit. Visits 1 and 2 are at least 2 days apart. Number of Participants: A maximum of 15 participants will be enrolled to study intervention such that 12 evaluable participants complete the study

Who can participate

Age range18 Years – 40 Years

SexALL

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Exclusion criteria

✕. Any medical condition limiting physical exertional capacity or requiring regular medication (allergy and contraceptives excepted).
✕. Pregnancy.
✕. Breastfeeding.
✕. History of syncope (syncope of presumed vasovagal nature with known precipitating factor excepted).
✕. Any known cardiac arrhythmia. Prior/Concomitant Therapy
✕. Any drug (contraceptives excepted) used on a regular basis for a chronic condition (allergy excepted).

What they're measuring

Cardiac stroke volume

Timeframe: 120 minutes

Trial details

NCT IDNCT05705115

SponsorOslo University Hospital

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2024-07-29

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