By InvitationNot Applicable

The Diabetes Prevention Program Outcomes Study AD/ADRD Project

United States1,976 participantsStarted 2022-11-07

Plain-language summary

The DPPOS AD/ADRD project will address the overarching question: What are the determinants and the nature of cognitive impairment among persons with pre-diabetes (PreD) and type 2 diabetes (T2D), who are a high-risk group for cognitive impairment and represent a large fraction of the United States (US) population? This U19 proposal addresses the National Alzheimer's Project Act goal to "prevent, halt, or reverse AD" in the high-risk group of persons with pre-diabetes and type 2 diabetes, who represent over half of the population aged 60 years and older in the US.

Who can participate

SexALL

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Inclusion Criteria: * All surviving participants originally randomized in the Diabetes Prevention Program * For Brain Imaging subcohort, only participants aged 55 years and older and those without contraindication to MRI will be included. Contraindications to MRI include the inability to lie flat, claustrophobia, and the presence of indwelling metallic objects, medical or non-medical, that are not 3T MRI compatible. Exclusion Criteria: \-

What they're measuring

Cognitive Diagnoses

Timeframe: Sept 2022 to October 2026

Trial details

NCT IDNCT05704309

SponsorMarinella Temprosa

Sponsor typeOTHER

Study typeOBSERVATIONAL

Primary completion2027-01-31

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