The UPDATE Trial (Uvb Phototherapy in Dermatology for ATopic Eczema)

Inclusion Criteria: * Adult (≥18 years of age) patient meeting the UK working party criteria for atopic eczema; * AE insufficiently controlled by standard topical care and therefore eligible for NB-UVB or OTT; * Investigator Global Assessment (IGA, 0-4) of ≥ 2 (moderate disease); * Eczema Area and Severity Index (EASI) of ≥ 7 (moderate disease); * Understood and voluntarily signed and dated an informed consent form prior to any study-related procedure or has a legal representative who has, and is willing to comply with the study's requirements. Exclusion Criteria: * Contra-indication for NB-UVB; * Genetic defects associated with photosensitivity or skin cancer; * Heavily photo-damaged skin; * History of multiple (\>1) skin malignancies; * Use of systemic immunosuppressants/immunomodulators; * Use of medication associated with photosensitivity; * Patient is already on systemic AE therapy; * Patient is already on OTT in the past 2 months; * NB-UVB or any systemic therapy in the past 9 months.