Active — Not RecruitingNot Applicable

Investigation of the Neurovegetative Pattern in Patients With Thoracic Aortic Aneurysms (TAA)

Italy139 participantsStarted 2021-11-09

Plain-language summary

The goal of this observational cross-sectional study is to learn about vagal features in patients with syndromic and non-syndromic TAA. The main question it aims to answer is to highlight a functional condition that could help stratify patients with TAA on the risk of aortic complications. Participant will take part by standing in supine position for 10 minutes and during active standing for 10 minutes. In this period of time, it will be possible to acquire the signals continuously and non invasively through recorded non-invasive blood pressure and piezoelectric sensor breathing belt.

Who can participate

Age range18 Years – 65 Years

SexALL

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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * Patients aged 18-65 years with syndromic and nonsyndromic TAA; * Signed informed consent; * Patients on regular pharmacological prophylaxis (with Losartan) or naïve patients with a first diagnosis Exclusion Criteria: * Acute and chronic inflammatory diseases such as: liver disease, chronic renal insufficiency (creatinine \> 1.5 mg/dl) and diseases affecting the thyroid system.

What they're measuring

Supine resting (REST) and active standing (STAND)

Timeframe: 18 months

Trial details

NCT IDNCT05703893

SponsorIRCCS Policlinico S. Donato

Sponsor typeOTHER

Study typeOBSERVATIONAL

Primary completion2024-10-25

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