The goal of this Nutrition for Precision Health (NPH) powered by All of Us research study is to develop Artificial Intelligence/Machine Learning (AI/ML) algorithms that predict individual responses to diet patterns using rich multimodal data streams collected across multiple domains (e.g., behavior, social, environmental, clinical and molecular biomarkers). NPH includes a large phenotyping cohort (Module 1, N=8000) and two separate follow-up groups drawn from a subset of Module 1participants. One group (Module 2, N=1200) receives three distinct diets in a 14-day crossover sequence, with at least a 14-day washout period between diets, while living in their own homes. A second group (Module 3, N=150) receives the same three diets under full-time supervision in a residential research setting. We will train and test AI/ML models to predict 0-4 hour postprandial response curves for glucose, insulin, triglycerides, and GLP-1, to the standardized diet-specific meal test (DSMT) collected after each of the three different diets delivered in Module 2. Each diet functions as a controlled stimulus to reveal biological features (such as individual variables, patterns, or clusters of measurements) that best predict a person's response. The Module 2 DSMT response curves are the primary outcomes (dependent variables) for AI/ML algorithms that predict individual responses to diet patterns. As a secondary objective, NPH will evaluate the validity and acceptability of technology-based dietary assessment tools. The Automated Self-Administered 24-hour recall (ASA24), Automatic Ingestion Monitor-2 (AIM-2), and the mobile food record (mFR) will be evaluated in Modules 2 and 3, and the ASA24 food record and the image-assisted ASA24 recall will be evaluated only in Module 3. Total energy intake, macronutrient and dietary fiber intake data are the main outcomes for validity testing compared against measures of actual intake. Acceptability will be determined from feedback surveys.
Age range
18 Years
Sex
ALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.
Glucose - Diet Specific mixed meal tolerance test (MMTT) Diet A
Timeframe: 4 hours
Insulin - Diet Specific mixed meal tolerance test (MMTT) Diet A
Timeframe: 4 hours
Triglycerides - Diet Specific mixed meal tolerance test (MMTT) Diet A
Timeframe: 4 hours
GLP-1 - Diet Specific mixed meal tolerance test (MMTT) Diet A
Timeframe: 4 hours
Glucose - Diet Specific mixed meal tolerance test (MMTT) Diet B
Timeframe: 4 hours
Insulin - Diet Specific mixed meal tolerance test (MMTT) Diet B
Timeframe: 4 hours
Triglycerides - Diet Specific mixed meal tolerance test (MMTT) Diet B
Timeframe: 4 hours
GLP-1 - Diet Specific mixed meal tolerance test (MMTT) Diet B
Timeframe: 4 hours
Glucose - Diet Specific mixed meal tolerance test (MMTT) Diet C
Timeframe: 4 hours
Insulin - Diet Specific mixed meal tolerance test (MMTT) Diet C
Timeframe: 4 hours
Triglycerides - Diet Specific mixed meal tolerance test (MMTT) Diet C
Timeframe: 4 hours
GLP-1 - Diet Specific mixed meal tolerance test (MMTT) Diet C
Timeframe: 4 hours