UnknownNot Applicable

Point-of-Care Echocardiography to Assess Impact of Dynamic Cardiac Function, Renal and Cardiac Biomarkers in Cirrhosis With Refractory Ascites

India80 participantsStarted 2022-11-15

Plain-language summary

Point-of-care echocardiography (POC-Echo) is used to determine left ventricular systolic and diastolic dysfunction (LVDD), inferior vena cava (IVC) dynamics and volume status in cirrhosis and Acute-on-chronic liver failure ACLF accurately. We will assess IVC dynamics, LV systolic function \[LV ejection fraction (EF) \& cardiac output (CO)\], and diastolic dysfunction (E/e', e' and E/A ratio) and urinary biomarkers (cystatin C and NGAL) in patients with cirrhosis and Refractory Ascites.

Who can participate

Age range18 Years – 65 Years

SexALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * Cirrhosis of any Etiology * Patient with Refractory Ascites Exclusion Criteria: * Hepatocellular carcinoma * Patients with active variceal bleeding * HIV or severe immunocompromised state * Chronic kidney disease (CKD) on renal replacement therapy (RRT), * Previous transjugular intra hepatic portosystemic shunt (TIPS) * Porto-pulmonary hypertension, * Coronary artery disease * Congenital or valvular heart disease * Prosthetic cardiac valves

What they're measuring

Cardiac output measurement by echocardiography after albumin

Timeframe: Day 0

Cardiac output measurement by echocardiography after albumin

Timeframe: Day 1

Cardiac output measurement by echocardiography after albumin

Timeframe: Day 2

Cardiac output measurement by echocardiography after albumin

Timeframe: Day 3

Trial details

NCT IDNCT05700708

SponsorPost Graduate Institute of Medical Education and Research, Chandigarh

Sponsor typeOTHER

Study typeOBSERVATIONAL

Primary completion2023-11-15

Contact for this trial

Madhumita Premkumar

01722754777 drmadhumitap@gmail.com

View on ClinicalTrials.gov More Cirrhosis, Liver trials

Plain-language summary

Who can participate

Age range18 Years – 65 Years

SexALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

What they're measuring

Cardiac output measurement by echocardiography after albumin

Timeframe: Day 0

Cardiac output measurement by echocardiography after albumin

Timeframe: Day 1

Cardiac output measurement by echocardiography after albumin

Timeframe: Day 2

Cardiac output measurement by echocardiography after albumin

Timeframe: Day 3