Nasal Spray Study in Sjogren's Dry Eye Disease

Inclusion Criteria: * Provide signed written consent prior to study-related procedures * Be at least 18 years of age at the screening visit * Have diagnosed moderate to severe Sjogrens Syndrome via blood work or biopsy Category 2 staining score for Conjunctiva based on the Van Bjisterveld and Utrect scale and 3 staining score for cornea based on the NEI scale * Have been using Cyclosporine or Lifitegrast 3 months * Be literate and able to complete questionnaires independently * Be able and willing to use the study drug and participate in all study assessments and visits * Have sufficient hand strength, in the opinion of the Investigator, to be able to independently administer the study drug * Have provided verbal and written informed consent * If a female is of childbearing potential, they must: use an acceptable means of birth control (acceptable methods of contraception include: hormonal oral, implantable, injectable, or transdermal contraceptives, mechanical spermicide in conjunction with a barrier such as a diaphragm or condom, IUD, or surgical sterilization of partner), and have a negative urine pregnancy test on Day 1 Exclusion Criteria: Have undergone previous ocular surgery (e.g., intraocular, oculoplastic, corneal or refractive surgical procedure) * Have had thermal pulsation or IPL in prior 3 months * Have used topical ophthalmic corticosteroid therapy in prior 4 weeks * Have had cataract surgery in the last 6 months * Have clinically significant ocular trauma. …