Study to Evaluate the Safety, Tolerability, and Efficacy of OTX-TKI in Subjects With Moderately Severe to Severe Non-proliferative Diabetic Retinopathy

Inclusion Criteria: * Are at least 18 years of age or older * Moderately severe to severe NPDR in the study eye defined as: DRSS levels of 47 or 53 as determined by the reading center * Diabetes type 1 or 2 * BCVA ETDRS letter score in the study eye of ≥69 letters (approximate Snellen equivalent of 20/40 or better) Exclusion Criteria: * DME within 6 months involving the center of the macula in the study eye * Presence of DME threatening the center (within 200 microns) of the macula in the study eye * OCT CSFT of ≥320 μm in the study eye