Hemoperfusion Efferon СT for the Treatment of Patients With Acute Pancreatitis

Inclusion Criteria: * Age ≥18 years old, * Verified diagnosis of "Acute pancreatitis" according to the Atlanta classification of acute pancreatitis (2012), without signs of infection, * No more than 72 hours from the onset of an attack of acute pancreatitis to hemosorption, * The patient's condition allows for therapy with the Efferon CT device for at least 4 hours. Exclusion Criteria: * History of chronic pancreatitis (exacerbation of chronic pancreatitis), * The presence of a focus of non-sanitized surgical infection, * The use of other methods of extracorporeal removal of inflammatory mediators in the treatment of pancreatitis (hemofilters with highly permeable and surface-modified membranes), * Inability to achieve or maintain a minimum mean arterial pressure (MAP) ≥ 65 mmHg. Art., despite vasopressor therapy and infusion therapy for 24 hours, * End-stage renal disease, and the need for chronic dialysis, * Acute pulmonary embolism, * Transfusion reaction, * Severe congestive heart failure, * The patient has had an acute myocardial infarction within the last 4 weeks, * Uncontrolled bleeding (acute blood loss in the last 24 hours), * Severe granulocytopenia (white blood cell count less than 500 cells/mm3) or severe thrombocytopenia, * Oncopathology out of remission.