Safety and Tolerability of VGR-R01 for Patients With Bietti Crystalline Dystrophy (NCT05694598) | Clinical Trial Compass
Active — Not RecruitingPhase 1
Safety and Tolerability of VGR-R01 for Patients With Bietti Crystalline Dystrophy
China12 participantsStarted 2023-03-27
Plain-language summary
A Multicenter, Open-Label, Non-Randomized, Uncontrolled Study of VGR-R01 in Patients with Bietti Crystalline Dystrophy.
Who can participate
Age range
18 Years – 69 Years
Sex
ALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion criteria
. Able to provide informed consent and comply with requirements of the study;
. ≥18 years and \<70 years of age;
. Confirmed diagnosis of Bietti Crystalline Dystrophy and molecular diagnosis of CYP4V2 mutations (homozygotes or compound heterozygotes);
. BCVA ≤ 60 ETDRS letters in the study eye.
Exclusion criteria
. Have insufficient viable retinal photoreceptor cells based on investigator's decision;
. Have current ocular or periocular infections, or endophthalmitis;
. Have any significant ocular disease/disorder other than BCD, including age-related macular degeneration, diabetic retinopathy, optic neuropathy, significant lens opacity, glaucoma, uveitis, retinal detachment, etc;
. Have intraocular surgery history except cataract surgery in the study eye;
. Have or potentially require of systemic medications that may cause eye injure;
. Have contraindications for corticosteroids or immunosuppressant;
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.
What they're measuring
1
Incidence of adverse events
Timeframe: Baseline up to Week 52
2
Incidence of serious adverse events
Timeframe: Baseline up to Week 52
3
Number of Participants with Clinically Significant Change from Baseline in Vital Signs
Timeframe: Baseline up to Week 52
4
Number of Participants with Clinically Laboratory Abnormalities
Timeframe: Baseline up to Week 52
5
Number of Participants with Clinically Significant Change from Baseline in Ophthalmic Examination Findings