UnknownPhase 4

Effect of Esmolol on Perioperative Stress Reaction

46 participantsStarted 2023-02-01

Plain-language summary

The goal of this clinical trial is to observe the effect of low dose continuous infusion of esmolol on perioperative stress response in patients undergoing airway intervention .

Who can participate

Age range18 Years – 85 Years

SexALL

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Inclusion criteria

✓. American Society of Anesthesiologists (ASA) Physical Status I to III.;
✓. Body mass index (BMI): 20-30 kg/m2;
✓. Elective airway intervention under general anesthesia with jet ventilation，duration of operation less than 2hs;
✓. Sign informed consent for clinical trial

Exclusion criteria

✕. The patient and his or her family refused to participate in the study;
✕. Severe respiratory or/cardiovascular or/ neurological disease, or/ hepatic or/renal dysfunction
✕. Those who are allergic to the drugs used in this study;
✕. Psychiatric history or with unstable mental state;
✕. Patients with atrioventricular block
✕. Patients with history of asthma
✕. Patients now treated with β-adrenergic receptor blockers
✕. Patients participating in other clinical trial

What they're measuring

Changes in plasma norepinephrine levels

Timeframe: up to 30 minutes after beginning of operation

Changes in plasma epinephrine levels

Timeframe: up to 30 minutes after beginning of operation

Changes in plasma cortisol levels

Timeframe: up to 30 minutes after beginning of operation

Trial details

NCT IDNCT05694585

SponsorXiumei Song

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2023-12-31

Contact for this trial

Xiumei Song, M.D.

13969050425 ssm801117@163.com

View on ClinicalTrials.gov More Esmolol trials