CompletedNot Applicable

Micro and Macro Circulation in Sepsis

United States68 participantsStarted 2022-07-01

Plain-language summary

Purpose: To assess the prognostic role of Handheld Vital Microscopy (HVM) and evaluate levels of endothelial glycocalyx (eGC) breakdown in patients demonstrating Hemodynamic Incoherence (HI), to elucidate a mechanistic link between the eGC and HI in order to inform prognostic enrichment of future resuscitation trials. We will serially evaluate microhemodynamics (MiH) and macro hemodynamics (maH) and the perfused boundary region (PBR, an visual proxy for eGC thickness) using HVM, and a validated circulating biomarker of eGC integrity.

Who can participate

Age range18 Years – 99 Years

SexALL

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Inclusion criteria

✓. Greater than or equal to 18 years of age
✓. Diagnosed with sepsis or septic shock
✓. Require admission to the Hospital
✓. Greater than or equal to 18 years of age
✓. Undergoing elective surgery requiring intubation and general anesthesia

Exclusion criteria

✕. Less than 18 years old
✕. Chronic Kidney disease on dialysis
✕. Currently pregnant
✕. Incarcerated persons
✕. Less than 18 years old
✕. History of Chronic Kidney disease on dialysis, uncontrolled diabetes, cirrhosis, heart failure, or nephritic or nephrotic syndromes.
✕. Currently pregnant
✕. Incarcerated persons

What they're measuring

Initiation and Duration Renal Replacement Therapy

Timeframe: 90 day

Trial details

NCT IDNCT05694455

SponsorDenver Health and Hospital Authority

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2025-05-31

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