CompletedPhase 4

Dexamethasone vs Ondansetron After Cesarean Delivery

United States100 participantsStarted 2023-03-30

Plain-language summary

The goal of this clinical trial is to compare medications in women having a cesarean delivery. The main question it aims to answer are: • Which medication is better to use as a first-line prevention agent for nausea and vomiting Participants will rate their nausea, pain and other symptoms after surgery Researchers will compare two drugs, ondansetron and dexamethasone to see if the side effects of pain medications are improved after cesarean.

Who can participate

Age range18 Years – 45 Years

SexFEMALE

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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * Healthy women (ASA 2) * Between 18 and 45 years old * Singleton term pregnancies * Scheduled or non-labor cesarean delivery * Neuraxial (spinal or combined-spinal epidural) anesthesia Exclusion Criteria: * Refusal to participate * Known allergy or contraindication to any medication used in the study * Significant medical or obstetrical disease (ASA ≥ 3) * Antiemetic use within 24 hours preceding cesarean delivery * Insulin dependent diabetes * Hyperemesis gravidarum or chronic antiemetic use * History of daily or near-daily steroid use during pregnancy * Opioid use disorder or other chronic pain syndrome * Opioid use during pregnancy * Use of antipruritus medication, pruritic urticarial papules of pregnancy, or cholestasis of pregnancy

What they're measuring

Medications Received

Timeframe: 24 hours

Trial details

NCT IDNCT05692245

SponsorBeth Israel Deaconess Medical Center

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2024-04-30

Results submitted2026-01-24

View on ClinicalTrials.gov More Nausea and Vomiting, Postoperative trials