Bile Acids Metabolism and Genetic Mutation Profile in the ICP in the Indian Population

Inclusion Criteria - * Age \> 21 years with consistent pruritus * Characterized by consistent pruritus associated with elevated levels of serum transaminases (ALT \> 40 U/L or AST \> 37 U/L) or raised total serum bile acids (≥ 10 µmol/L) * Able to understand and comply with the requirements of the study and voluntarily agrees to participate in the study by giving written informed consent before any study-related activity is performed * Voluntary informed consent to participate until their delivery and also willing to be followed until their delivery * Agrees to provide information on perinatal and maternal outcomes at or after delivery Exclusion Criteria: * Viral and Infectious diseases such as hepatitis B virus (HBV), hepatitis C virus (HCV) related liver disease, Epstein Barr virus (EBV), Cytomegalovirus (CMV), human immunodeficiency virus (HIV) infection) hepatitis C virus (HBV), hepatitis E virus (HEV) * Primary dermatologic diseases associated with pruritus * Metabolic diseases (including alcohol abuse) * Other causes of cholestasis (i.e., primary biliary cholangitis (PBC); primary sclerosing cholangitis (PSC) * Autoimmune liver disease * Obstructive biliary diseases * Cholestatic drug-induced liver injury * Clinical severe conditions that may affect outcomes include heart failure, renal failure, primary cardiopulmonary diseases * Twins and triplet pregnancy