CompletedNot Applicable

Dietary Antioxidants and Thiol Disulfide Homeostasis in T2DM

Turkey (Türkiye)87 participantsStarted 2021-01-03

Plain-language summary

This observational study was planned to determine the relationship between dietary antioxidant intake and thiol disulfide homeostasis of individuals with type 2 diabetes. One of the current approaches in medical nutrition therapy of diabetes is to increase the consumption of foods with high antioxidant content in order to strengthen antioxidant defense. Increased dietary antioxidant intake may have both protective and therapeutic effects by reducing the risk of diabetes and preventing complications that may occur. It is known that dynamic thiol disulfide balance can be a good indicator of antioxidant defense in individuals with diabetes, and there are limited studies on this subject.

Who can participate

Age range

30 Years – 50 Years

Sex

ALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria (for case group): * Diagnosis with type 2 diabetes mellitus * Diabetes age for a maximum of 5 years * Body mass index (BMI)\<30 kg/m\^2 * Received and applied medical nutrition therapy and metformin therapy Inclusion Criteria (for control group): * Body mass index (BMI) \<30 kg/m\^2 Exclusion Criteria (for case group): * Receiving insulin therapy * Developing diabetes-specific complications * Smoking tobacco * Consuming alcohol * Having end-stage chronic renal failure * Receiving chemotherapy and/or radiotherapy * Being in menopause, pregnant and/or lactation period * Using antioxidant vitamin and mineral supplements Exclusion Criteria (for control group): * Smoking tobacco * Using alcohol * Having any chronic disease * Having end-stage chronic renal failure * Receiving chemotherapy and/or radiotherapy * Being in menopausal, pregnant and/or lactation period, * Using antioxidant vitamin and mineral supplements * Following any diet program

Questions worth asking your doctor

Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.

1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?

Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.

Questions for the trial coordinator

The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.

1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?

A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.

What they're measuring

Serum native thiol level

Timeframe: Baseline (preprandial in the morning)

Serum disulphide level

Timeframe: Baseline (preprandial in the morning)

Serum total thiol level

Timeframe: Baseline (preprandial in the morning)

Disulphide/native thiol ratio

Timeframe: Baseline (preprandial in the morning)

Disulphide/total thiol ratio

Timeframe: Baseline (preprandial in the morning)

Native thiol/total thiol ratio

Timeframe: Baseline (preprandial in the morning)

Dietary antioxidant capacity

Timeframe: Baseline

Trial details

NCT IDNCT05688631

SponsorAnkara Yildirim Beyazıt University

Sponsor typeOTHER

Study typeOBSERVATIONAL

Primary completion2021-03-12

View on ClinicalTrials.gov More Diabetes Mellitus, Type 2 trials

Plain-language summary

Who can participate

Age range

30 Years – 50 Years

Sex

ALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

What they're measuring

Serum native thiol level

Timeframe: Baseline (preprandial in the morning)

Serum disulphide level

Timeframe: Baseline (preprandial in the morning)

Serum total thiol level

Timeframe: Baseline (preprandial in the morning)

Disulphide/native thiol ratio

Timeframe: Baseline (preprandial in the morning)

Disulphide/total thiol ratio

Timeframe: Baseline (preprandial in the morning)

Native thiol/total thiol ratio

Timeframe: Baseline (preprandial in the morning)

Dietary antioxidant capacity

Timeframe: Baseline