Effects of Cephalaria Syriaca Flour-added Bread on Glucose Metabolism and Appetite Parameters in … (NCT05687812) | Clinical Trial Compass
CompletedNot Applicable
Effects of Cephalaria Syriaca Flour-added Bread on Glucose Metabolism and Appetite Parameters in Individuals With Obesity, Diabetes, and Healthy Controls.
Turkey (Türkiye)60 participantsStarted 2022-01-01
Plain-language summary
Cephalaria Syriaca is a common weed in Anatolia and grows wild in wheat fields, with high fat, protein, and dietary fiber content. This study it is aimed to evaluate the effects of lowering the glycemic index of white bread consumed in large quantities in Turkey by adding Cephalaria Syriaca, on healthy, obese, and diabetic individuals.
Who can participate
Age range
18 Years – 65 Years
Sex
ALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria:
Healthy group (n=20):
* 18-65 years of age, non-obese and non-diabetic healthy individuals
* OGTT is normal
* Body Mass Index (BMI)= 18.5-24.9 kg/m2
Diabetic group (n=20):
• Individuals aged between 18-65 years with Type 2 Diabetes
* Using only metformin
* BMI= 18.5-29.9 kg/m2
Obese group (n=20):
• 18-65 years of age, non-diabetic and obese individuals;
\- BMI ≥ 30 kg/m2
Exclusion Criteria:
Individuals with
* Smoking
* Use Alcohol
* Pregnant
* Breastfeeding
* Those with chronic diseases (CKD, COPD, Malignancy,..)
* Using food supplements
* Using DPP-4 inhibitors and GLP-1release analog in the treatment of DM
* Professional athlete or excessive physical activity
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.
What they're measuring
1
Plasma GLP-1 levels changes
Timeframe: Through OGTT test completion, an average of 2 hours
2
Plasma PYY levels changes
Timeframe: Through OGTT test completion, an average of 2 hours
3
Plasma Leptin levels changes
Timeframe: Through OGTT test completion, an average of 2 hours
4
Plasma Ghrelin levels changes
Timeframe: Through OGTT test completion, an average of 2 hours
5
Plasma IL-6 levels changes
Timeframe: Through OGTT test completion, an average of 2 hours
6
Plasma insulin levels changes
Timeframe: Through OGTT test completion, an average of 2 hours
7
Plasma glucose levels changes
Timeframe: Through OGTT test completion, an average of 2 hours