Remiazolam Combined With Esketamine in Painless Bidirectional Endoscopy in Children

Inclusion Criteria: * Age 0-17; * ASA Class I-II; * Sign the informed consent form. Exclusion Criteria: * Patients with high risk of stomach satiety and reflux aspiration; * Patients allergic to the study drug; * Obesity or severe malnutrition; * Those who have taken sedative, analgesic or antidepressant drugs within 24 hours; * Hypertension without treatment; * Abnormal liver and kidney function (index ≥ 2 times the upper limit of normal reference range); * Other congenital diseases or acute and chronic diseases that affect the observation of curative effect; * Participate in other clinical studies within 4 weeks.