UnknownNot Applicable

Clinical and Radiographic Evaluation of the Synergistic Effect of Nano Silver Particles and Calcium Hydroxide Versus Triple Antibiotic Paste as Antibacterial Agents for Lesion Sterilization and Tissue Repair (LSTR) in Necrotic Primary Molars

22 participantsStarted 2023-02-20

Plain-language summary

Could the clinical and radiographic success of Nano Silver Particles and Calcium Hydroxide be comparable to that of Triple Antibiotic Paste as antibacterial agents for Lesion Sterilization and Tissue Repair (LSTR) in necrotic second primary molars?

Who can participate

Age range

4 Years – 7 Years

Sex

ALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * Children aged between 4 years and 7 years. * Restorable necrotic mandibular second primary molars * Mandibular lower second primary molar with signs of radiolucency in periapical or furcation area. * Mandibular lower second primary molar with widening of PDL space or loss of lamina dura continuity. * Mandibular lower second primary molar with evidence of internal/external pathologic root resorption. Signs of radiolucency in periapical or furcation area. * Widening of PDL space or loss of lamina dura continuity. * Evidence of internal/external pathologic root resorption. * External root resorption from 1% to 50%. Exclusion Criteria: * Children that are not apparently healthy. * Lack of informed consent by the child patient's parent. * Patients allergic to any antibiotic used in the preparation of the TAP. * Unable to attend follow-up visits. * Refusal of participation. * External root resorption above 50%.

Questions worth asking your doctor

Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.

1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?

Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.

Questions for the trial coordinator

The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.

1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?

A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.

What they're measuring

Pathological mobility

Timeframe: 1 year.

Post-operative pain

Timeframe: 1 year.

Soft tissue pathology

Timeframe: 1 year.

Pain to percussion

Timeframe: 1 year.

Trial details

NCT IDNCT05681221

SponsorCairo University

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2024-03-01

Contact for this trial

Sohair M. Aly, BSc

+201006202025 sohair_magdy@dentistry.cu.edu.eg

View on ClinicalTrials.gov More Root Canal Infection trials

Who can participate

Age range

4 Years – 7 Years

Sex

ALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.