This research project aims at better understanding the early biological effects resulting from occupational exposure to complex Polycyclic Aromatic Hydrocarbon (PAH) mixtures. Current biomarkers used as part of biomonitoring campaigns are biomarkers of exposure, not numerous and poorly related to health effects. The aim of this study is thus to improve our understanding of biological consequences of such exposures, both in terms of proteins deregulation, metabolism deregulation and genotoxicity.
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Deregulation of blood proteins expression due to exposure to PAHs
Timeframe: up to 6 months between both periods of study
Deregulation of blood metabolites expression due to exposure to PAHs
Timeframe: up to 6 months between both periods of study
Frequency of micronuclei measured due to exposure to PAHs
Timeframe: up to 6 months between both periods of study