By InvitationNot Applicable

Pain, Central Sensitization and Psychoemotional State in Patients With Chronic Masticatory Muscle Pain

Poland102 participantsStarted 2023-09-01

Plain-language summary

The aim of this study is to investigate the relationship of psychological aspects, selected blood parameters, pain, central sensitization, and muscle electromyography activity in patients with chronic masticatory muscle pain.

Who can participate

Age range18 Years – 80 Years

SexALL

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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria for study group: * Masticatory muscle pain for at least 3 months, based on DC/TMD, at least 18 y.o Exclusion Criteria: * severe neurological or psychiatric diseases, use of drugs that may affect the neuromuscular system, alcohol or drug addiction, cancer or pregnancy, previous head surgery Inclusion criteria for control group: * no pain in masticatory muscles, age of at least 18 y.o Exclusion criteria the same as for study group

What they're measuring

Relationship between masticatory muscle pain and polimorphism of serotonin receptor gene HTR2A - rs4941573 and dopamine receptor gene DRD3 - rs6280

Timeframe: January 3, 2023 - January 3, 2024

Relationship between masticatory muscle pain and serotonin and dopamine levels.

Timeframe: January 3, 2023 - January 3, 2024

Relationship between masticatory muscle pain and Gamma-aminobutyric acid (GABA), Tumor Necrosis Factor α (TNF-α), CGRP, SERT, interleukin 1B, interleukin 6, interleukin 8, interleukin 10 and interleukin 17A.

Timeframe: January 3, 2023 - January 3, 2024

Trial details

NCT IDNCT05676827

SponsorWroclaw Medical University

Sponsor typeOTHER

Study typeOBSERVATIONAL

Primary completion2026-12

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