To Evaluate the Beneficial Effect of Probiotics on DKD Patients and the Role of Gut Microbiota Modulation

Inclusion Criteria: * Age between 25 and 80 years old * Suffering from type 2 diabetes and stable medication for 3 months * Detection of HbA1c before meals between 7% and 10% * Stage 1-3a diabetic nephropathies (eGFR \> 45 mL/min) * Microalbuminuria estimated between 30 to 300 mg/day Exclusion Criteria: * Patients with Type I Diabetes Mellitus * Patients with inflammatory bowel disease, liver disease, liver cirrhosis, systemic lupus erythematosus, malignancy, and high blood pressure. * Patients with hypoglycemic coma, Diabetic ketoacidosis, hyperosmolar non-ketotic diabetic coma, or diabetes mellitus acute complications. * Acute infection medical history in past 3 month * Fasting blood glucose \>13.3 mmol/L * GPT\>100U/L (2.5 times than usual situation) * Vulnerable population (Including breeding or pregnant women, prisoner, aboriginal, disabled population) * Smoker or Alcoholic * Taking Antibiotics in past 1 month * Stably taking probiotics supplements in past 1 months (Yogurt or dairy products were excluded) * Taking immunosuppressive drug, angiotensin-converting enzyme inhibitors, or angiotensin receptor blockers in past 3 months