Effect of Probiotics on Eradication of Persistent H.Pylori Infection

Inclusion Criteria: * Symptomatic patients with persistent H. pylori infection of both sexes aged ≥ 18 years old years whose infection was previously confirmed by endoscopy and pathology and experienced ≥ 2 previous treatment failures. Exclusion Criteria: * Patients with penicillin allergy. * Patients who have severe renal or hepatic disease. * Patients who have severe cardiovascular, endocrinological or pulmonary disease. * Patients with neoplastic diseases in the 5 years previous to recruitment. * Patients with neurological or psychiatric pathology. * Pregnant and/or lactating females * Patients with a history of allergic reactions to any medications used in the study. * Patients with a history of taking proton pump inhibitors, H2 antagonists, bismuth, or antibiotics (amoxicillin, metronidazole, clarithromycin) in the previous 2 weeks. * Patients on N-acetylcysteine * Patients on drug or alcohol abuse in the past year.