CompletedNot Applicable

NIRST and ICG-based Perfusion Imaging in Acute Compartment Syndrome

United States15 participantsStarted 2023-05-12

Plain-language summary

This is a prospective observational study of patients with suspected Acute Compartment Syndrome. The primary objective of this work is to determine whether intensity changes associated with the NIRST signal, reflecting oxy- and deoxy-hemaglobin and water concentrations or ICG fluorescence signal, reflecting tissue perfusion, can be associated with development of Acute Compartment Syndrome and identification of at-risk soft tissue and muscle.

Who can participate

Age range18 Years

SexALL

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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * Age 18 years or older * Clinical suspicion of acute compartment syndrome based on orthopaedic provider assessment. Clinical suspicion would be based upon the presence of one or more of these findings: * Pain out of proportion to visible findings * Escalating doses of pain medication * Pain with passive stretch of toes and/or fingers * Pallor, paresthesias, pulselessness * Tense soft tissues * High energy tibia or forearm fracture * Provision of informed consent Exclusion Criteria: * History of allergy to ICG and/or iodine * Pregnant women or nursing mothers * Any patient with an open wound for whom NIRST device cannot be applied \>4cm from the open wound will be excluded from NIRST imaging.

What they're measuring

Association of NIRST or ICG measurements with development of ACS

Timeframe: 36 months

Trial details

NCT IDNCT05672381

SponsorDartmouth-Hitchcock Medical Center

Sponsor typeOTHER

Study typeOBSERVATIONAL

Primary completion2025-09-16

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