CompletedNot Applicable

Effects of Oral Xylitol on Subsequent Energy Intake

Switzerland21 participantsStarted 2023-01-27

Plain-language summary

The aim of this project is to investigate the effect of xylitol (given as pre-load), compared to sucrose, Ace-K, and water on energy intake during a subsequent ad libitum test meal in healthy participants. Furthermore, the release of GI hormones, glycemic control, appetite-related sensations, GI tolerance, sweetness and liking in response to the pre-loads will be investigated.

Who can participate

Age range18 Years – 55 Years

SexALL

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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * Healthy normal weight participants (10 male and 10 female) with a body-mass index (BMI) of 19.0-24.9 kg/m2 * Age 18-55 years * Stable body weight (± 5%) for at least three months * Able to give informed consent as documented by signature Exclusion Criteria: * Fructose intolerance * Pre-existing diet (vegetarian, vegan, sugar free, no breakfast) * Pre-existing regular consumption of xylitol and/or Ace-K (\> 1/week) * Chronic or clinically relevant acute infections/diseases * Regular intake of medications, except contraceptives * Pregnancy: although no contraindication, pregnancy might influence metabolic state. * Substance abuse (more than 1 glass wine/beer per day; consumption of cannabis, cocaine, heroin, etc.) * Shift worker * Participation in another study with investigational drug within the 30 days preceding and during the present study

What they're measuring

Effect of xylitol on energy intake during a subsequent ad libitum test meal

Timeframe: Total energy intake will be measured from t = 0 until t = 20 minutes or as soon as the as the subject stops eating for more than 5 minutes.

Trial details

NCT IDNCT05671965

SponsorUniversity Hospital, Basel, Switzerland

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2024-01-31